Isoflavones – plant-based active ingredients with anti-aging effects in skincare

What are isoflavones?

Isoflavones are secondary plant compounds belonging to the group of phytoestrogens , meaning plant substances that have a structure similar to the body's own estrogen. They are found primarily in soybeans, red clover, and other legumes and have antioxidant, skin-smoothing, and hormone-like effects—without the side effects of synthetic hormones.^¹

How do isoflavones affect the skin?

Isoflavones bind to estrogen receptors in skin cells, promoting collagen synthesis, elastin production, and moisture retention. Particularly in mature skin, they can slow down the decline in skin density and reduce the appearance of fine lines. ^{^2,3}

• Anti-aging effect: Isoflavones stimulate cell regeneration and improve skin elasticity.
• Antioxidant protection: Neutralize free radicals and protect against UV-induced skin aging.
• Moisture retention: Supports the synthesis of the skin's own lipids.
• Hormonal balance: Reduces typical skin changes during menopause.

Isoflavones in cosmetics

In modern formulations, isoflavones are usually derived from soy or red clover extracts . They are found in serums, anti-aging creams, and intensive treatments, often in combination with peptides, hyaluronic acid, or ceramides. Their effects are particularly pronounced with long-term use.

Products containing isoflavones are generally suitable for dry, mature, or hormonally affected skin – that is, from around the mid-40s onwards, when natural estrogen levels decline. ⁴

Scientific findings

Studies show that topically applied isoflavones can increase skin thickness and reduce wrinkle depth. Regular use over several weeks leads to a measurable improvement in skin hydration and elasticity. ^{5 , 6}

In vitro studies also show that isoflavones have anti-inflammatory effects and reduce oxidative stress in skin cells.

Isoflavones in natural cosmetics

In natural cosmetics – such as those from NATURFACTOR – isoflavones from soy or red clover are used in combination with biotechnological antioxidants to promote skin regeneration naturally. They are ideally suited as part of a regenerative skincare routine for demanding skin.

Safety and compatibility

Topically ^applied isoflavones are considered safe. According to the German Federal Institute for Risk Assessment (BfR), there is no hormonal risk associated with external application. Unlike dietary supplements, the substance is not absorbed systemically but acts locally on the skin.

Conclusion

Isoflavones are natural, effective agents that combat skin aging and dryness. They improve elasticity and moisture, protect against free radicals, and balance hormonal changes. Their combination with modern active ingredients makes them a key component of effective anti-aging cosmetics.

Sources

1. Wikipedia (DE): Isoflavones. https://de.wikipedia.org/wiki/Isoflavones
2. Federal Centre for Nutrition (BZfE): Isoflavones in food. https://www.bzfe.de/inhalt/isoflavone-in-lebensmitteln-28962.html
3. DocCheck Flexikon: Phytoestrogens. https://flexikon.doccheck.com/de/Phyto%C3%B6strogene
4. NetDoktor (DE): Isoflavones – plant estrogens. https://www.netdoktor.de/ernaehrung/isoflavone/
5. Springer Medicine: Effects of plant isoflavones on the skin. https://link.springer.com/article/10.1007/s00105-019-04501-2
6. Charité University Medicine Berlin – Dermatological research on phytoestrogens. https://derma.charite.de/forschung/
7. BfR: Assessment of isoflavones in cosmetic products. https://www.bfr.bund.de/de/a-z_index/isoflavone-2048.html